Interstate 69 (I-69) is an Interstate Highway in the United States. It exists in two parts: a completed highway from Indianapolis, Indiana, northeast to the Canadian border in Port Huron, Michigan, and a mostly-proposed extension southwest to the Mexican border in Texas. Of this extension, nicknamed the NAFTA Superhighway, since it would help trade with Canada and Mexico spurred by the North American Free Trade Agreement, only a short piece in northwestern Mississippi has been built and marked as I-69 (see Interstate 69 in Mississippi).

The southern terminus of the existing portion is at Interstate 465, the beltway around Indianapolis, on the northeast side of that city. I-69 heads northeast, past Anderson, Muncie, Marion, and Fort Wayne, Indiana; the latter city is served by Interstate 469, I-69's only current signed auxiliary route. After crossing the Indiana Toll Road (I-80/I-90) near Angola, I-69 enters Michigan, crossing I-94 east of Battle Creek and joining with I-96 for an overlap west of Lansing. Where it splits from I-96, I-69 turns east, both in compass direction and in signed direction, and heads north of Lansing and through Flint (where it crosses I-75) to a junction with I-94 in Port Huron. The last bit of I-69 overlaps I-94 to the Blue Water Bridge across the St. Clair River, where traffic continues on Highway 402 in the Canadian province of Ontario.

In addition to the main line of I-69, the overall project - known as Corridors 18 and 20 of the National Highway System - also includes Interstate 94 between Chicago and Port Huron, and several spurs from I-69. Among these proposed spurs are an extension of Interstate 530 from Pine Bluff, Arkansas, an upgrade of U.S. Route 59 from Texarkana, Texas, and a split in southern Texas to serve three border crossings at Laredo, Pharr, and Brownsville. In August 2007 I-69 was selected by the USDOT as one of six Corridors of the Future, making it eligible for additional federal funding and streamlined planning and review.

I-69 map